Effects of Cyclosporine on Activated T-Cell Expression of IL-2 and IFN-gamma in Dogs (Study Closed)
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Study Start Date: 05/01/2016
Study End Date: 05/01/2017
Effects of Cyclosoprine on Activated T Cell Expression of IL-2 and IFN-gamma in Dogs
Dogs with anal furunculosis are often treated with the immunosuppressive drug cyclosporine. Our laboratory has developed an assay, "activated T- cell expression of IL-2 and IFN-gamma", to fine tune cyclosporine doses. Interpretation of the assay is optimized by knowing pre-treatment levels. Our laboratory has good pre-treatment assay data for most diseases, but lacks sufficient samples from dogs with anal furunculosis.
Study Design:
Case series for assay validation
Sample Size:
15 samples
Inclusion Criteria:
- Canine anal furunculosis, diagnosed based on classic clinical appearance that has not yet been treated with cyclosporine.
Exclusion Criteria:
- Anal furunculosis that has been treated with cyclosporine
Samples:
A single blood sample from dogs in the early treatment phases of anal furunculosis, before they receive cyclosporine. A single 3 ml heparinized sample, collected and submitted in the first half of the week, will suffice.
Study Website:
Further sample submission details are on our web- site: http://www.cvm.msstate.edu/animal-health-center/pharmacodynamic-laboratory
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Costs/Reimbursements
For the first 15 samples sent in for the anal furunculosis baseline project, we are offering the next post-cyclosporine T cell assay (whether on the anal furunculosis patient, or another patient) at no charge. Just remind us when you are submitting another clinical sample.
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Full Disclosure information:
The study is funded by a grant from Mississippi State University.
The investigator does not have a conflict of interest.